Which drug has analgesia and euphoria as uses?

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Opioid analgesics produce analgesia and often euphoria because they activate mu receptors in the brain, which lowers pain perception and can produce a pleasant, rewarding sensation. Among the options, morphine is the classic opioid that provides both strong analgesia and euphoria, reflecting its potent mu-agonist activity. This combination is a defining feature of morphine’s clinical use as a powerful analgesic with subjective euphoria.

Naloxone is an opioid antagonist, so it reverses analgesia and euphoria rather than producing them. Flumazenil is a benzodiazepine receptor antagonist and has no analgesic or euphoric effect. Meperidine is an opioid analgesic and can cause euphoria as well, but it has a higher risk profile (short duration, potential neurotoxicity from metabolites) and is not as representative of the classic analgesia-plus-euphoria combination as morphine.