For avulsion injuries, what is the recommended single-dose doxycycline regimen (with standard adult equivalence for >45 kg)?

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In avulsion injuries, providing antibiotic coverage quickly and succinctly helps prevent infection and may reduce resorption around the replanted tooth. Doxycycline given as a single dose achieves effective tissue levels against the mixed oral flora, including anaerobes and Actinomyces, without requiring a prolonged course. For patients who weigh more than 45 kg, the standard adult dose is 100 mg, which corresponds to a weight-based dose of about 2.2 mg/kg given just once. This one-time approach balances adequate antibacterial activity with minimizing antibiotic exposure and the potential for resistance or adverse effects. Doxycycline is typically avoided in younger children due to effects on developing teeth, so the single-dose regimen is particularly framed for those above the 45 kg threshold. The other regimens involve longer courses or different antibiotics and are not the recommended single-dose approach for this clinical scenario.